Realize offers targeting based on a variety of audience types:
Broad Targeting - also known as run of network, where the predictive algorithm works to find the right audience
Advertiser 1st Party - also for retargeting purposes
Taboola Pixel audiences
File based audiences - available in the US, Canda, UK, France, Germany, Spain, Italy, Israel, Greece, Switzerland, Uruguay, Portugal, Turkey, India, Japan, Singapore, Australia, New Zealand, Brazil, Mexico, Argentina, Colombia, South Africa, Puerto Rico, Panama, Azerbaijan
Lookalikes - based off a CRM file and available only in the USAudience data marketplace - including both Realize's 1st party data and 3rd party segments
You can combine different audiences together, however it's important to note that too many audience overlays can result in limited reach.
It's important to always check the reach estimator to understand what you're scaling ability is like when overlaying audience targeting to your campaigns.